|
KMID : 0614020000160010052
|
|
Journal of Pharmaceutical Sciences (C.N.U.)
2000 Volume.16 No. 1 p.52 ~ p.56
|
|
|
Monoamine Oxidase Inhibitors form Kaempferia galanga
|
|
Dang Thi Lan Huong
Lee Myung-Koo
Bae Ki-Hwan
Kim Young-Ho
|
|
|
Abstract
|
|
|
|
From the bioassay-directed fractionation and isolation of dichloromethane fraction of kaempferia galanga, five compounds having MAO inhibitory effect were isolated by repeated silica gel column chromatography. Their chemical structures were established as ethyl p-methoxy-trans-cinnamate (1), ethyl-trans-cinnamate (2), 6, 9-pentadecadien-2-one (3), β-sitosterol (4), and 3, 6-dimethoxy-frans-cinnamate (5) on the basis of their physicochemical and spectral data. Among these compounds, compound 1 and 5 showed high inhibitory activities in vitro against mouse brain MAO with IC_50 values were 5.0 μM and 20.2 μM, respectively. Compound 2 and 3 exhibited low inhibitory activities on MAO.
|
|
|
KEYWORD
|
|
|
Kaempferia galanga, monoamine oxidase inhibition, ethyl p-methoxy-trans-cinnamate, ethyl-trans-cinnamate, 6 , 9-pentadecadien-2-one, β-sitosterol, 3 , 6-dimethoxy-trans-cinnamate
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|